Catalog No.: PC-38239Not For Human Use, Lab Use Only.
MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
MS.001 also inhibits CHIP/chaperone interaction with IC50 of 3.8 uM.
MS.001 does not have activity against isolated U-box or tetratricopeptide (TPR) domains, but instead only inhibited full-length CHIP.
