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MS.001

Chemical Structure : MS.001

CAS No.: 53619-67-3

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MS.001 (CHIP inhibitor MS001)

Catalog No.: PC-38239Not For Human Use, Lab Use Only.

MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
    MS.001 also inhibits CHIP/chaperone interaction with IC50 of 3.8 uM.
    MS.001 does not have activity against isolated U-box or tetratricopeptide (TPR) domains, but instead only inhibited full-length CHIP.

    Physicochemical Properties

    M.Wt 303.292
    Formula C13H9N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-nitro-7-(p-tolylsulfinyl)benzo[c][1,2,5]oxadiazole

    References

    1. Kanack AJ, et al. Chembiochem. 2022 Mar 18;23(6):e202100633.

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