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BC1618

Chemical Structure : BC1618

CAS No.: 2222094-18-8

BC1618 (BC-1618)

Catalog No.: PC-72478Not For Human Use, Lab Use Only.

BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
BC1618 demonstrated greater potency in stimulating Ampk-dependent signaling than AICAR or metformin.
BC1618 increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.
BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in diet-induced obese mice.

Physicochemical Properties

M.Wt 415.456
Formula C24H24F3NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol

References

1. Liu Y, et al. Nat Chem Biol. 2021 Mar;17(3):298-306.

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