Catalog No.: PC-72478Not For Human Use, Lab Use Only.
BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
BC1618 demonstrated greater potency in stimulating Ampk-dependent signaling than AICAR or metformin.
BC1618 increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.
BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in diet-induced obese mice.
