Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PRC1 inhibitor RB-3
Catalog No.: PC-38305Not For Human Use, Lab Use Only.
PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.
RB-3 bind to RING1B by inducing the formation of a hydrophobic pocket in the RING domain.
RB-3 decreases the global level of H2A ubiquitination (IC50=1.6 uM) and induces differentiation in leukemia cell lines and primary AML samples.
RB-3 represents a valuable chemical tool to study PRC1 biology.
| M.Wt | 417.893 | |
| Formula | C24H20ClN3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Shukla S, et al. Nat Chem Biol. 2021 Jul;17(7):784-793.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
