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Chemical Structure : BC-1258
CAS No.: 1507370-40-2
Catalog No.: PC-38449Not For Human Use, Lab Use Only.
BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $438 | In stock | |
| 250 mg | Get quote |
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BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.
BC-1258 induced FBXL2 concentrations in a variety of cells, decreased FBXL2 substrates, including Aurora B in human leukemia cells.
BC-1258 induced apoptosis in leukemic cells by causing mitotic arrest and tetraploidy.
BC-1258 prematurely depleted Aurora B by SCFFBXL2-induced ubiquitination and degradation, BC-1258 (30 ug/ml in the drinking water) showed significant decreases in Aurora B protein levels and inhibited tumorigenesis on growth of U937 tumor implants in nude mice.
| M.Wt | 406.57 | |
| Formula | C22H22N4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N1,N2-Bis[[4-(2-thiazolyl)phenyl]methyl]-1,2-ethanediamine |
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1. B B Chen, et al. Cell Death Dis. 2013 Aug 8;4(8):e759.
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