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BC-1485

Chemical Structure : BC-1485

CAS No.: 2035085-19-7

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BC-1485 (BC1485)

Catalog No.: PC-61670Not For Human Use, Lab Use Only.

BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
    BC-1485 exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480.
    BC-1485 dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells.
    BC-1485 ameliorates fibrosis in murine models.

    Physicochemical Properties

    M.Wt 431.467
    Formula C19H21N5O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-(dimethylamino)-1-oxopropan-2-yl)-4-((2-oxo-2,3-dihydro-1H-benzo[d]imidazole)-5-sulfonamido)benzamide

    References

    1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46.

    2. Lear T, et al. Cytokine. 2016 Dec;88:193-195.

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