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Chemical Structure : BC-1485
Catalog No.: PC-61670Not For Human Use, Lab Use Only.
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
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BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
BC-1485 exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480.
BC-1485 dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells.
BC-1485 ameliorates fibrosis in murine models.
| M.Wt | 431.467 | |
| Formula | C19H21N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46.
2. Lear T, et al. Cytokine. 2016 Dec;88:193-195.
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