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Chemical Structure : CC-220
CAS No.: 1323403-33-3
Catalog No.: PC-60518Not For Human Use, Lab Use Only.
Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM.
CC-220 exhibits significantly higher affinity than lenalidomide and pomalidomide (IC50=1.5 and 1.2 uM, respectively).
CC-220 reduces and degrades Aiolos and Ikaros protein levels (EC50=1 nM and 0.5 nM, respectively) and BAFF- and CD40L-induced proliferation, plasmablast differentiation, and IgG secretion in cellular degradation assay.
| M.Wt | 449.5 | |
| Formula | C25H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
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1. Matyskiela ME, et al. J Med Chem. 2017 Apr 20. doi: 10.1021/acs.jmedchem.6b01921.
2. Nakayama Y, et al. J Immunol. 2017 Oct 1;199(7):2388-2407.
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