Skp2 inhibitor E35 | Skp2 inhibitor | Probechem Biochemicals

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Chemical Structure : Skp2 inhibitor E35

Skp2 inhibitor E35 (HK-E35)

Catalog No.: PC-24708Not For Human Use, Lab Use Only.

Skp2 inhibitor E35 (HK-E35) is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 4.8 uM against Skp2-Cks1 binding.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Skp2 inhibitor E35 (HK-E35) is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 4.8 uM against Skp2-Cks1 binding.
E35 significantly inhibited colony formation and migration, as well as arrested the cell cycle at the S-phase.
E35 markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27.
E35 showed an obvious inhibitory effect on MGC-803 xenograft mice without obvious toxicity.

Physicochemical Properties

M.Wt	471.37
Formula	C21H19BrN4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-bromobenzyl)thio)-7-(2,4-dimethoxyphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

References

1. Hu K, et al. J Med Chem. 2024 Sep 26;67(18):16435-16454.

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Skp2 inhibitor E35 (HK-E35)

Biological Activity

Physicochemical Properties

References

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