Chemical Structure : OICR-41103
CAS No.:
OICR-41103
(OICR41103)
Catalog No.: PC-25147Not For Human Use, Lab Use Only.
OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.
shows no affinity for a panel of six WDR proteins up to 20 uM.
OICR-41103 binds and engages the WDR domain of DCAF1 in cells, effectively thermally stabilized the WDR domain of DCAF1 with EC50 of 165 nM.
OICR-41103 displaces HIV viral accessory protein Vpr from the DCAF1 WDR domain.
Physicochemical Properties
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M.Wt
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575.44
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Formula
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C28H26Cl2F2N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S,E)-N-(3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)-4-(4-chloro-2-fluorophenyl)-5-(3-oxo-3-(piperidin-1-yl)prop-1-en-1-yl)-1H-pyrrole-3-carboxamide
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References
1. Kimani SW, et al. Commun Biol. 2025 Jul 19;8(1):1076.
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