NEDD4 inhibitor 32

Chemical Structure : NEDD4 inhibitor 32

Catalog No.: PC-24781Not For Human Use, Lab Use Only.

NEDD4 inhibitor 32 is a selective, covalent inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination.

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Biological Activity

NEDD4 inhibitor 32 is a selective, covalent and cell-active inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination.

Physicochemical Properties

M.Wt	369.90
Formula	C20H24ClN5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((4-(8-chloro-1-methyl-4,5-dihydrobenzo[b]pyrazolo[4,3-f]azepin-10(1H)-yl)butyl)amino)but-2-enenitrile

References

1. Maspero E, et al. Commun Chem. 2025 May 28;8(1):164.

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