SB33-0223 | TRIM21 inhibitor | Probechem Biochemicals

Chemical Structure : SB33-0223

SB33-0223 (SB 33-0223)

Catalog No.: PC-27969Not For Human Use, Lab Use Only.

SB33-0223 is a small molecule inhibitor of E3 ubiquitin ligase TRIM21, targets the C-terminal PRYSPRY domain of the TRIM21 protein, inhibits TRIM21-mediated ubiquitination of INTS3 by weakening the TRIM21-INTS3 interaction, attenuates cisplatin-induced DNA damage.

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Biological Activity

SB33-0223 is a small molecule inhibitor of E3 ubiquitin ligase TRIM21, targets the C-terminal PRYSPRY domain of the TRIM21 protein, inhibits TRIM21-mediated ubiquitination of INTS3 by weakening the TRIM21-INTS3 interaction, attenuates cisplatin-induced DNA damage.

Physicochemical Properties

M.Wt	362.44
Formula	C20H22N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[(3R,4S)-4-(3-methyl-1H-1,2,4-triazol-5-yl)-1-(3-pyridinylmethyl)-3-pyrrolidinyl]-, rel-

References

1. Xinyi Dong, et al. Apoptosis. 2026 Aug 31;31(9):216.

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SB33-0223 (SB 33-0223)

Biological Activity

Physicochemical Properties

References

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