Chemical Structure : XZA-1
CAS No.:
1282141-20-1
XZA-1
(XZA1)
Catalog No.: PC-25921Not For Human Use, Lab Use Only.
XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.
XZA-1 activates HADH, a key enzyme in fatty acid β-oxidation, resulting in increased intracellular levels of acetoacetyl-CoA.
XZA-1 promotes acetoacetylation of CBX4 at lysine 106, thereby reducing its SUMO E3 ligase activity.
XZA-1 demonstrated antitumor effects by enhancing CBX4 K106 acetoacetylation in CBX4-overexpressing xenograft model.
Physicochemical Properties
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M.Wt
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256.31
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Formula
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C15H16N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-phenyl-5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxamide
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References
1. Li H, et al. Cell Chem Biol. 2025 Oct 16;32(10):1249-1259.e9.
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