| Cat. No. |
Product Name |
Information |
| PC-24919 |
LY-364947
TGFβR1 inhibitor
|
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II. |
| PC-24853 |
RK783
ACVR1 inhibitor
|
RK783 is a potent, selective inhibitor inhibitor of BMP type 1 receptor kinase (ACVR1), inhibits CVR1-Q207D, ACVR1-R206H, wild-type ACVR1, and other BMP type 1 receptor kinases with IC50 of 10-120 nM. |
| PC-24165 |
Ontunisertib
ALK5 inhibitor
|
Ontunisertib is a potent, selective TGF-beta type I receptor (TGFβRI)/ALK5 kinase inhibitor. |
| PC-23803 |
C-5635020
TGFβ RII inhibitor
|
C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol. |
| PC-23416 |
CDD-2789
ALK2/ALK1 inhibitor
|
CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM. |
| PC-22017 |
M4K2149
ALK2 inhibitor
|
M4K2149 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 17 nM, 34-fold selective over ALK5 (IC50=756 nM). |
| PC-22016 |
M4K2306
ALK2 inhibitor
|
M4K2306 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 7 nM, >500-fold selective over ALK5. |
| PC-22015 |
M4K2009
ALK2 inhibitor
|
M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM). |
| PC-22014 |
M4K2304
ALK2 inhibitor
|
M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5. |
| PC-21885 |
SRI-35241
TGF-β inhibitor
|
SRI-35241 is a potent inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.12 nM, 79% inhibition at 100 nM. |
| PC-21884 |
SRI-31277
TGF-β inhibitor
|
SRI-31277 is a tripeptide inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.28 nM. |
| PC-21393 |
LDN-212854
ALK2 inhibitor
|
LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM). |
