Cat. No. |
Product Name |
Information |
PC-22015 |
M4K2009
ALK2 inhibitor
|
M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM). |
PC-22014 |
M4K2304
ALK2 inhibitor
|
M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5. |
PC-21885 |
SRI-35241
TGF-β inhibitor
|
SRI-35241 is a potent inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.12 nM, 79% inhibition at 100 nM. |
PC-21884 |
SRI-31277
TGF-β inhibitor
|
SRI-31277 is a tripeptide inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.28 nM. |
PC-21393 |
LDN-212854
ALK2 inhibitor
|
LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM). |
PC-49752 |
Ki26894
TβR-I kinase inhibitor
|
Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM. |