| Cat. No. |
Product Name |
Information |
| PC-45749 |
EW-7197
ALK5 inhibitor
|
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (TGF-βRI, ALK5) with IC50 of 11 nM. |
| PC-26694 |
M4K2308
ALK2 inhibitor
|
M4K2308 is a potent, selective inhibitor of ALK2 with IC50 of 2 nM, >100-fold selectivity over ALK5. |
| PC-26693 |
M4K2163 dihydrochloride
ALK2 inhibitor
|
M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor with IC50 of 19 nM. |
| PC-25943 |
KTI-2338
ALK2 inhibitor
|
KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1. |
| PC-24983 |
YH395A
TGF-βRI inhibitor
|
YH395A is a specific inhibitor of TGFβ receptor 1 (TGFβR1) with MST KD of 35.6 uM, abrogates Smad-dependent signaling in TNBC. |
| PC-24982 |
YR-290
TGF-βRI inhibitor
|
YR-290 is a specific inhibitor of TGFβ receptor 1 (TGFβR1) with IC50 of 137 nM, exhibits anticancer activity of IC50 value of 9.13 μM against A549 cell. |
| PC-24919 |
LY-364947
TGFβR1 inhibitor
|
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II. |
| PC-24165 |
Ontunisertib
ALK5 inhibitor
|
Ontunisertib is a potent, selective TGF-beta type I receptor (TGFβRI)/ALK5 kinase inhibitor. |
| PC-23803 |
C-5635020
TGFβ RII inhibitor
|
C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol. |
| PC-23416 |
CDD-2789
ALK2/ALK1 inhibitor
|
CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM. |
| PC-22017 |
M4K2149
ALK2 inhibitor
|
M4K2149 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 17 nM, 34-fold selective over ALK5 (IC50=756 nM). |
| PC-22016 |
M4K2306
ALK2 inhibitor
|
M4K2306 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 7 nM, >500-fold selective over ALK5. |
