Chemical Structure : A 83-01
CAS No.:
909910-43-6
A 83-01
(A83-01, A-83-01)
Catalog No. : PC-42582Not For Human Use, Lab Use Only.
A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4258201
Biological Activity
A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
Physicochemical Properties
M.Wt
421.5168
Formula
C25H19N5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
References
1. Tojo M, et al. Cancer Sci.
2. Yuan X, et al. Stem Cells.
3. Yamamura S, et al. Int J Cancer.
4. Minowa T, et al. Br J Cancer.
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