ALK5 inhibitor 20

Chemical Structure : ALK5 inhibitor 20

Catalog No.: PC-26849Not For Human Use, Lab Use Only.

ALK5 inhibitor 20 is a potent, selective and lung-restricted ALK5 inhibitor with pKi of 10.13, shows persistent and lung-restricted target engagement in a pharmacodynamic model, shows remarkable efficacy in idiopathic pulmonary fibrosis (IPF).

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Biological Activity

Physicochemical Properties

M.Wt	546.06
Formula	C25H29ClFN7O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((6-(5-chloro-2-fluorophenyl)-3-((2-hydroxyethyl)thio)pyridazin-4-yl)amino)pyridin-2-yl)-3-(4-methylpiperazin-1-yl)propanamide

References

1. Ronchi P, et al. J Med Chem. 2026 May 18. doi: 10.1021/acs.jmedchem.5c03825.

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