LDN-214117 |CAS:1627503-67-6 Probechem Biochemicals

Chemical Structure : LDN-214117

CAS No.: 1627503-67-6

LDN-214117 (LDN214117)

Catalog No.: PC-45058Not For Human Use, Lab Use Only.

LDN-214117 (LDN214117) is a potent and selective ALK2 inhibitor with a biochemical IC50 of 24 nM, a cell-based IC50 for BMP6 of 100 nM.

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Biological Activity

LDN-214117 (LDN214117) is a potent and selective ALK2 inhibitor with a biochemical IC50 of 24 nM, a cell-based IC50 for BMP6 of 100 nM.
LDN-214117 displays 164-fold selectivity for BMP6 versus TGF-β1.
LDN-214117 is a highly selective probe of BMP-mediated cellular physiology.

Physicochemical Properties

M.Wt	419.5161
Formula	C25H29N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-

References

1. Mohedas AH, et al. J Med Chem. 2014 Oct 9;57(19):7900-15.

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LDN-214117 (LDN214117)

Biological Activity

Physicochemical Properties

References

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