| Cat. No. |
Product Name |
Information |
| PC-42940 |
K02288
BMP receptor inhibitor
|
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4. |
| PC-42935 |
DMH-1
BMP inhibitor
|
DMH-1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively. |
| PC-42858 |
SB-525334
ALK5 inhibitor
|
SB-525334 (SB525334) is a potent and selective inhibitor of TGF-β1 receptor (ALK5) inhibitor with IC50 of 14,5 nM, 4-fold less potent against ALK4 and inactive for ALK2, ALK3, and ALK6 (IC50>10 uM). |
| PC-63129 |
LY3200882
ALK5 inhibitor
|
LY3200882 (LY-3200882) is a novel potent, highly selective, ATP competitive TGF-β receptor type 1 (TGFβRI, ALK5) inhibitor with IC50 of 38.2 nM. |
| PC-61455 |
TASP0382088
ALK5 inhibitor
|
TASP0382088 is a potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases. |
| PC-61454 |
TP-0427736
ALK5 inhibitor
|
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3. |
| PC-61453 |
ALK5-IN-16i
ALK5 inhibitor
|
ALK5-IN-16i is a potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3. |
| PC-61448 |
IN-1233 phosphate
ALK5 inhibitor
|
IN-1233 phosphate is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery. |
| PC-61447 |
IN-1233
ALK5 inhibitor
|
IN-1233 is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery. |
| PC-61446 |
EW-7195
ALK5 inhibitor
|
EW-7195 (EW7195) is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α. |
| PC-60916 |
San78-130
ALK1 inhibitor
|
San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277. |
| PC-60915 |
L-783277
ALK1 inhibitor
|
L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM. |
