| Cat. No. |
Product Name |
Information |
| PC-22014 |
M4K2304
ALK2 inhibitor
|
M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5. |
| PC-21885 |
SRI-35241
TGF-β inhibitor
|
SRI-35241 is a potent inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.12 nM, 79% inhibition at 100 nM. |
| PC-21884 |
SRI-31277
TGF-β inhibitor
|
SRI-31277 is a tripeptide inhibitor of thrombospondin 1 activation of TGF-β, specifically inhibits TGF-β activation mediated through TSP-1 with pIC50 of 8.28 nM. |
| PC-21393 |
LDN-212854
ALK2 inhibitor
|
LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM). |
| PC-49752 |
Ki26894
TβR-I kinase inhibitor
|
Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM. |
| PC-49709 |
CDD-1281
BMPR2 inhibitor
|
CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM. |
| PC-49110 |
SY-LB-57
BMP receptor agonist
|
SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line. |
| PC-72168 |
BMS-986260
TGFβR1 inhibitor
|
BMS-986260 (BMS 986260) is a potent, selective, and orally bioavailable TGFβR1 inhibitor with IC50 of 1.6 nM, negligible inhibition against TGFβR2 (IC50>15 uM). |
| PC-35964 |
BMP signaling agonist sb4
|
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes. |
| PC-43322 |
RepSox
|
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM, can replace the central reprogramming factor Sox2 by inducing nanog. |
| PC-43290 |
R-268712
|
R-268712 is a potent, selective, orally active inhibitor of TGF-β type I receptor ALK5 with IC50 of 2.5 nM, >5,000-fold more selectivity than p38 MAPK. |
| PC-43159 |
ITD-1
|
ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2. |
