| Cat. No. |
Product Name |
Information |
| PC-70054 |
IN-1130
ALK5 inhibitor
|
IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM. |
| PC-70053 |
GW-6604
ALK5 inhibitor
|
GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay. |
| PC-42581 |
SB-431542
ALK5 inhibitor
|
SB-431542 (SB431542) is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM. |
| PC-42525 |
GW788388
ALK5 inhibitor
|
GW788388 is a potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay. |
| PC-42582 |
A 83-01
TGF-βRI inhibitor
|
A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively. |
| PC-42887 |
LY2109761
TGF-β RI/II inhibitor
|
LY2109761 is a potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively. |
| PC-45993 |
A 77-01
ALK5 inhibitor
|
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
| PC-45058 |
LDN-214117
ALK2 inhibitor
|
LDN-214117 (LDN214117) is a potent and selective ALK2 inhibitor with a biochemical IC50 of 24 nM, a cell-based IC50 for BMP6 of 100 nM. |
| PC-42176 |
FT011
Collagen synthesis inhibitor
|
FT011 (SHP-627) is an anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM). |
| PC-45749 |
EW-7197
ALK5 inhibitor
|
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (TGF-βRI, ALK5) with IC50 of 11 nM. |
| PC-24983 |
YH395A
TGF-βRI inhibitor
|
YH395A is a specific inhibitor of TGFβ receptor 1 (TGFβR1) with MST KD of 35.6 uM, abrogates Smad-dependent signaling in TNBC. |
| PC-24982 |
YR-290
TGF-βRI inhibitor
|
YR-290 is a specific inhibitor of TGFβ receptor 1 (TGFβR1) with IC50 of 137 nM, exhibits anticancer activity of IC50 value of 9.13 μM against A549 cell. |
