| Cat. No. |
Product Name |
Information |
| PC-70053 |
GW-6604
ALK5 inhibitor
|
GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay. |
| PC-42581 |
SB-431542
ALK5 inhibitor
|
SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM. |
| PC-42525 |
GW788388
ALK5 inhibitor
|
GW788388 is a potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay. |
| PC-42582 |
A 83-01
TGF-βRI inhibitor
|
A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively. |
| PC-42887 |
LY2109761
TGF-β RI/II inhibitor
|
LY2109761 is a potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively. |
| PC-45993 |
A 77-01
ALK5 inhibitor
|
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
| PC-45058 |
LDN-214117
ALK2 inhibitor
|
LDN-214117 (LDN214117) is a potent and selective ALK2 inhibitor with a biochemical IC50 of 24 nM, a cell-based IC50 for BMP6 of 100 nM. |
| PC-42176 |
FT011
Collagen synthesis inhibitor
|
FT011 (SHP-627) is an anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM). |
| PC-45749 |
EW-7197
ALK5 inhibitor
|
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (ALK5) with IC50 of 11 nM. |
| PC-23416 |
CDD-2789
ALK2/ALK1 inhibitor
|
CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM. |
| PC-22017 |
M4K2149
ALK2 inhibitor
|
M4K2149 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 17 nM, 34-fold selective over ALK5 (IC50=756 nM). |
| PC-22016 |
M4K2306
ALK2 inhibitor
|
M4K2306 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 7 nM, >500-fold selective over ALK5. |
