GW788388 is a potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay.
GW788388 displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.).
GW788388 has an IC50 of 93 nM in TGF-β cellular assay.
GW788388 presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.
