EW-7197 (Vactosertib) | ALK5 inhibitor

Chemical Structure : EW-7197

CAS No.: 1352608-82-2

EW-7197 (Vactosertib, EW7197, TEW-7197)

Catalog No.: PC-45749Not For Human Use, Lab Use Only.

EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (TGF-βRI, ALK5) with IC50 of 11 nM.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$148	In stock
50 mg	$248	In stock
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Biological Activity

EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (TGF-βRI, ALK5) with IC50 of 11 nM.
EW-7197 (Vactosertib, TEW-7197) also inhibits ALK4 (IC50=13 nM) and shows less potency for p38α (IC50=280 nM).
EW-7197 (Vactosertib, TEW-7197) exhibits no inhibition on ALK1/2/3/6 (>10 uM).
EW-7197 (Vactosertib, TEW-7197) inhibits Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice.
EW-7197 (Vactosertib, TEW-7197) shows oral bioavailability (Hcl salt).

Physicochemical Properties

M.Wt	399.4236
Formula	C22H18FN7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazole-2-methanamine,N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

References

1. Jin CH, et al. J Med Chem. 2014 May 22;57(10):4213-38.

2. Son JY, et al. Mol Cancer Ther. 2014 Jul;13(7):1704-16.

3. Yoon JH, et al. EMBO Mol Med. 2013 Nov;5(11):1720-39.

EW-7197 (Vactosertib, EW7197, TEW-7197)

Biological Activity

Physicochemical Properties

References

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