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GW-6604

Chemical Structure : GW-6604

CAS No.: 452342-37-9

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GW-6604 (GW6604, GW 6604)

Catalog No.: PC-70053Not For Human Use, Lab Use Only.

GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.
GW-6604 increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.

Physicochemical Properties

M.Wt 298.34
Formula C19H14N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine

References

1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77.

2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.

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