| Cat. No. |
Product Name |
Information |
| PC-72619 |
PF-06952229
TGFbR1 inhibitor
|
PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM. |
| PC-72168 |
BMS-986260
TGFβR1 inhibitor
|
BMS-986260 (BMS 986260) is a potent, selective, and orally bioavailable TGFβR1 inhibitor with IC50 of 1.6 nM, negligible inhibition against TGFβR2 (IC50>15 uM). |
| PC-35964 |
BMP signaling agonist sb4
BMP signaling agonist
|
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes. |
| PC-35812 |
AZ12799734
BMP/TGFβ inhibitor
|
AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM. |
| PC-35811 |
AZ12601011
TGFBR1 inhibitor
|
AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM. |
| PC-35519 |
BLU-782
ALK2 inhibitor
|
Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM. |
| PC-63322 |
JL5
BMP receptor inhibitor
|
JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively. |
| PC-43408 |
SD-208
TGF-βRI inhibitor
|
SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases. |
| PC-43407 |
LY2157299
TGF-βRI inhibitor
|
LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-β receptor I kinase ((TGF-βRI) with IC50 of 56 nM. |
| PC-43322 |
RepSox
ALK5 inhibitor
|
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM. |
| PC-43290 |
R-268712
ALK5 inhibitor
|
R-268712 is a potent, selective, orally active inhibitor of TGF-β type I receptor ALK5 with IC50 of 2.5 nM, >5,000-fold more selectivity than p38 MAPK. |
| PC-43159 |
ITD-1
TGF-β inhibitor
|
ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2. |
