Catalog No.: PC-43322Not For Human Use, Lab Use Only.
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM.
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM.
RepSox can replace the central reprogramming factor Sox2 by inducing nanog.
RepSox specifically acts by inhibiting Tgf-β signaling, does not act by inducing Sox2 expression in the target fibroblasts.
RepSox efficiently replaces transgenic Sox2 in the absence of VPA and c-Myc, as well as in both embryonic and adult fibroblasts; demonstrates effectivity at generating iPSCs.
