Chemical Structure : BLU-782
CAS No.:
2141955-96-4
BLU-782
(Fidrisertib, BLU782)
Catalog No.: PC-35519Not For Human Use, Lab Use Only.
Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.
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| 10 mg | $278 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | $798 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.
BLU-782 is selective for ALK2R206H over other BMP Type I ALK family receptors.
BLU-782 prevents injury-induced heterotopic ossification (HO) in an ALK2 R206H transgenic mouse model of FOP.
BLU-782 is an investigational ALK2 inhibitor in development for fibrodysplasia ossificans progressiva (FOP).
Physicochemical Properties
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M.Wt
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562.715
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Formula
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C31H42N6O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester
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References
1. PCT Int. Appl. (2017), WO 2017181117 A1 20171019.
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