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BLU-782

Chemical Structure : BLU-782

CAS No.: 2141955-96-4

BLU-782 (Fidrisertib, BLU782)

Catalog No.: PC-35519Not For Human Use, Lab Use Only.

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.
BLU-782 is selective for ALK2R206H over other BMP Type I ALK family receptors.
BLU-782 prevents injury-induced heterotopic ossification (HO) in an ALK2 R206H transgenic mouse model of FOP.
BLU-782 is an investigational ALK2 inhibitor in development for fibrodysplasia ossificans progressiva (FOP).

Physicochemical Properties

M.Wt 562.715
Formula C31H42N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester

References

1. PCT Int. Appl. (2017), WO 2017181117 A1 20171019.

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