PF-06952229 (MDV6058) | TGFbR1 inhibitor

Chemical Structure : PF-06952229

CAS No.: 1801333-55-0

PF-06952229 (MDV6058, PF 06952229)

Catalog No.: PC-72619Not For Human Use, Lab Use Only.

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM, specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction (94% inhibition of pSMAD at 0.5 uM), shows with potential antineoplastic activity.

Physicochemical Properties

M.Wt	458.918
Formula	C23H24ClFN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)amino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide

References

1. Brahmam Pujala, et al. Bioorg Med Chem Lett. 2022 Sep 8;128979.

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PF-06952229 (MDV6058, PF 06952229)

Biological Activity

Physicochemical Properties

References

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