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BMP signaling agonist sb4

Chemical Structure : BMP signaling agonist sb4

CAS No.: 100874-08-6

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BMP signaling agonist sb4

Catalog No.: PC-35964Not For Human Use, Lab Use Only.

BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes.
BMP signaling agonist sb4 increases the phosphorylation of key second messengers (SMADs-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, ID1 and ID3) in canonical BMP signaling.

Physicochemical Properties

M.Wt 320.204
Formula C14H10BrNOS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-bromobenzyl)thio)benzo[d]oxazole

References

1. Bradford STJ, et al. J Biol Chem. 2019 Jan 2. pii: jbc.RA118.006817.

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