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Chemical Structure : LY2157299
CAS No.: 700874-72-2
Catalog No.: PC-43407Not For Human Use, Lab Use Only.
LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-β receptor I kinase ((TGF-βRI) with IC50 of 56 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-β receptor I kinase ((TGF-βRI) with IC50 of 56 nM.
LY2157299 (Galunisertib) inhibits TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner, stimulates hematopoiesis from primary MDS bone marrow specimens.
LY2157299 (Galunisertib) ameliorates anemia in a TGF-β overexpressing transgenic mouse model of bone marrow failure.
LY2157299 (Galunisertib) displays significant antitumor activity against both Calu6 and MX1 xenografts in mice.
| M.Wt | 369.4192 | |
| Formula | C22H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
6-Quinolinecarboxamide, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]- |
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1. Zhou L, et al. Cancer Res. 2011 Feb 1;71(3):955-63.
2. Yoon JH, et al. EMBO Mol Med. 2013 Nov;5(11):1720-39.
3. Bhola NE, et al. J Clin Invest. 2013 Mar;123(3):1348-58.
4. Rodon J, et al. Clin Cancer Res. 2015 Feb 1;21(3):553-60.
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