| Cat. No. |
Product Name |
Information |
| PC-24588 |
GFH018
TGF-βRI inhibitor
|
GFH018 is a small molecule inhibitor of transforming growth factor-β receptor I (TGF-βRI, ALK5) inhibitor with IC50 of 40 nM, >60-fold selective over p38α MAPK. |
| PC-24274 |
HM-279
ALK5 inhibitor
|
HM-279 is a potent, selective, orally bioavailable inhibitor of ALK5 (TGFβR1) with IC50 of 4.7 nM, strongly inhibits the phosphorylation of Smad3 in A549 cells (IC50=21.6 nM). |
| PC-21414 |
TP-0184
ALK2 inhibitor
|
Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2). |
| PC-21392 |
NUCC-555
Activin inhibitor
|
NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM. |
| PC-49711 |
CDD-1115
BMPR2 inhibitor
|
CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM. |
| PC-49710 |
CDD-1653
BMPR2 inhibitor
|
CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases. |
| PC-49709 |
CDD-1281
BMPR2 inhibitor
|
CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM. |
| PC-49110 |
SY-LB-57
BMP receptor agonist
|
SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line. |
| PC-49109 |
SY-LB-35
BMP receptor agonist
|
SY-LB-35 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line. |
| PC-72619 |
PF-06952229
TGFbR1 inhibitor
|
PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM. |
| PC-72168 |
BMS-986260
TGFβR1 inhibitor
|
BMS-986260 (BMS 986260) is a potent, selective, and orally bioavailable TGFβR1 inhibitor with IC50 of 1.6 nM, negligible inhibition against TGFβR2 (IC50>15 uM). |
| PC-35964 |
BMP signaling agonist sb4
BMP signaling agonist
|
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes. |
