Chemical Structure : NUCC-555
CAS No.:
1060469-90-0
NUCC-555
(NUCC555)
Catalog No.: PC-21392Not For Human Use, Lab Use Only.
NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
NUCC-555 binds to the activin A:ActRII that disrupts the activin A:ActRII complex's binding with ALK4-ECD-Fc in a dose-dependent manner.
NUCC-555 also specifically binds to activin A compared with other TGFβ superfamily member myostatin (GDF8).
NUCC-555 completely blocks activin A/ActRIIA complex binding with ALK4 at 25 uM, shows no blocking activity to the myostatin/ActRIIA complex binding with ALK4.
NUCC-555 not only strongly antagonizes function against activin A but also has selectivity for binding to activin A over other TGFβ superfamily members, such as myostatin.
NUCC-555 (30 or 60 mg/kg) treatment induces a dose-dependent decrease in FSH levels in ovariectomized mice.
Physicochemical Properties
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M.Wt
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443.51
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Formula
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C25H25N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-benzyl-1-ethyl-5-(2-methoxyacetamido)-2-(pyridin-3-yl)-1H-benzo[d]imidazole-7-carboxamide
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References
1. Jie Zhu, et al. J Med Chem. 2015 Jul 23;58(14):5637-48.
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