M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).
M4K2209 shows cell IC50 of 26 nM in NanoBRET target engagement assay.
M4K2209 is equipotent against both wild-type (WT) and mutant ALK2 (G328V, R206H, and R258G) in the biochemical kinase assay.
M4K2009 is also moderately active against the hERG potassium channel (IC50= 8 uM).
