M4K2009

Chemical Structure : M4K2009

Catalog No.: PC-22015Not For Human Use, Lab Use Only.

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).

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Biological Activity

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).
M4K2209 shows cell IC50 of 26 nM in NanoBRET target engagement assay.
M4K2209 is equipotent against both wild-type (WT) and mutant ALK2 (G328V, R206H, and R258G) in the biochemical kinase assay.
M4K2009 is also moderately active against the hERG potassium channel (IC50= 8 uM).

Physicochemical Properties

M.Wt	419.53
Formula	C25H29N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine

References

1. Ensan D, et al. J Med Chem. 2020 May 14;63(9):4978-4996.

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M4K2009

Biological Activity

Physicochemical Properties

References

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