Catalog No.: PC-49110Not For Human Use, Lab Use Only.
SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.
SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.
SY-LB-57 (0.01-10 uM) stimulated canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways, similar to BMP2-stimulated responses.
SY-LB-57strongly stimulate Smad phosphorylation and nuclear translocation, induce robust increases in PI3K/Akt signaling.
SY-LB-57 is a full agonists of BMP receptor signaling.
Physicochemical Properties
M.Wt
263.300
Formula
C16H13N3O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(5-methoxy-1H-indol-2-yl)-1H-benzo[d]imidazole
References
1. Sheyda Najafi, et al. Sci Rep. 2022 Jul 15;12(1):12146.
