GFH018 | TGF-βRI inhibitor | Probechem Biochemicals

Chemical Structure : GFH018

GFH018 (GFH-018)

Catalog No.: PC-24588Not For Human Use, Lab Use Only.

GFH018 is a small molecule inhibitor of transforming growth factor-β receptor I (TGF-βRI, ALK5) inhibitor, blocks TGF-β signal transduction, inhibits the progression and/or metastasis of advanced cancers.

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Biological Activity

Physicochemical Properties

M.Wt	385.43
Formula	C21H19N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)acrylamide

References

1. Guo Y, et al. BMC Cancer. 2024 Apr 10;24(1):444.

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GFH018 (GFH-018)

Biological Activity

Physicochemical Properties

References

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