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Chemical Structure : SD-208
CAS No.: 627536-09-8
Catalog No.: PC-43408Not For Human Use, Lab Use Only.
SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $388 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases.
SD-208 inhibits the growth inhibition of TGF-beta-sensitive CCL64 cells mediated by recombinant TGF-β1 or TGF-β2 or of TGF-β-containing glioma cell supernatant with EC50 of 0.1 uM.
SD-208 inhibits constitutive and TGF-β–induced invasion of glioma cells, inhibits TGF-β signaling in immune effector cells.
SD-208 blocks TGF-β signaling in the brain and inhibits the growth of syngeneic SMA-560 experimental gliomas in vivo.
| M.Wt | 352.7529 | |
| Formula | C17H10ClFN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl- |
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1. Uhl M, et al. Cancer Res. 2004 Nov 1;64(21):7954-61.
2. Bonniaud P, et al. Am J Respir Crit Care Med. 2005 Apr 15;171(8):889-98.
3. Zhou L, et al. Blood. 2008 Oct 15;112(8):3434-43.
4. Hayashi T, et al. Clin Cancer Res. 2004 Nov 15;10(22):7540-6.
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