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JL5

Chemical Structure : JL5

CAS No.: 2244238-50-2

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JL5 (BMP receptor inhibitor JL5)

Catalog No.: PC-63322Not For Human Use, Lab Use Only.

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.
    JL5 shows much weaker acitivity against BMPR2, ALK5/TGFβR1 and TGFβR2 with IC50 of 8,510, 440 and 40 nM.
    JL5 shows a greater volume of distribution and suppresses the expression of Id1 and pTak1 in tumor xenografts, induces tumor cell death and tumor regression in xenograft mouse models without immune cells and humanized with adoptively transferred human immune cells.

    Physicochemical Properties

    M.Wt 449.558
    Formula C28H27N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)propyl)morpholine

    References

    1. Newman JH, et al. Oncogene. 2018 Apr 6. doi: 10.1038/s41388-018-0156-9.

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