Catalog No.: PC-70054Not For Human Use, Lab Use Only.
IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM.
IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM.
IN-1130 is highly selective in a panel of 27 serine/threonine and tyrosine kinases including p38α.
IN-1130 decreases levels of TGF-beta1 mRNA, type I collagen mRNA, and pSmad2, compared to UUO control rats.
IN-1130 inhibits renal fibrosis in obstructive nephropathy in vivo models.
