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ALK5-IN-16i

Chemical Structure : ALK5-IN-16i

CAS No.: 864375-44-0

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ALK5-IN-16i (ALK5 inhibitor 16i)

Catalog No.: PC-61453Not For Human Use, Lab Use Only.

ALK5-IN-16i is a potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALK5-IN-16i is a potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.
    ALK5-IN-16i inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM).
    ALK5-IN-16i significantly decreases Smad2 phosphorylation in mouse skin after topical application.
    ALK5-IN-16i may serves as a potential new therapy for AGA.

    Physicochemical Properties

    M.Wt 427.541
    Formula C20H21N5O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    isobutyl ((5-(benzo[d]thiazol-6-yl)-4-(4-methylthiazol-2-yl)-1H-imidazol-2-yl)methyl)carbamate

    References

    1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.

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