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San78-130

Chemical Structure : San78-130

CAS No.: 66018-45-9

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San78-130 (San 78-130)

Catalog No.: PC-60916Not For Human Use, Lab Use Only.

San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277.
    San78-130 inhibits (>80%) only 6 kinases including ALK1, FLT3, FLT4, KDR, MEK2 and MKK6 in a panel of 342 kinases, shows weak inhibition for other ALK isotypes.
    San78-130 suppresses the BMP9-induced Smad1/5 pathway by mainly inhibiting ALK1 in C2C12 cells, promotes angiogenesis in both endothelial tube formation and microfluidic chip based 3D angiogenesis assays

    Physicochemical Properties

    M.Wt 366.41
    Formula C19H26O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,8S,9S)-8,9,16-Trihydroxy-14-methoxy-3-methyl-3,4,5,6,9,10,11,12-octahydro-1Hbenzo[c][1]oxacyclotetradecine-1,7(8H)-dione

    References

    1. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.

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