TASP0382088 |CAS:1253941-85-3 Probechem Biochemicals

Chemical Structure : TASP0382088

TASP0382088 (TASP-0382088)

Catalog No.: PC-61455Not For Human Use, Lab Use Only.

A potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases.

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Biological Activity

TASP0382088 is a potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases.
TASP0382088 inhibits TGF-β-induced Smad2/3 phosphorylation at cellular level with IC50 of 17 nM.
TASP0382088 inhibits Smad2 phosphorylation in mouse skin after topical application.

Physicochemical Properties

M.Wt	328.408
Formula	C15H12N4OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole

References

1. Amada H, et al. Chem Pharm Bull (Tokyo). 2013;61(3):286-91.

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TASP0382088 (TASP-0382088)

Biological Activity

Physicochemical Properties

References

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