IN-1233 | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : IN-1233

IN-1233 (IN1233, IN 1233)

Catalog No.: PC-61447Not For Human Use, Lab Use Only.

IN-1233 is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery.

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Biological Activity

IN-1233 is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery.

Physicochemical Properties

M.Wt	419.488
Formula	C26H21N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamide

References

1. Kim JH, et al. Radiology, May 2013 Volume 267, Issue 2, doi.org/10.1148/radiol.12120361

2. Kim JH, et al. Radiology. 2010 Apr;255(1):75-82.

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IN-1233 (IN1233, IN 1233)

Biological Activity

Physicochemical Properties

References

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