TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
TP-0427736 inhibits Smad2/3 phosphorylation in A549 cells (IC50=8.7 nM) and decreases the growth inhibition of human outer root sheath cells.
TP-0427736 significantly decreases Smad2 phosphorylation in mouse skin after topical application, may serves as a potential new therapy for AGA.
