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Chemical Structure : EW-7195
CAS No.: 1352609-28-9
Catalog No.: PC-61446Not For Human Use, Lab Use Only.
A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $348 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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EW-7195 (EW7195) is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α.
EW-7195 decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells.
EW-7195 inhibits metastasis to lung from breast tumours in xenografted mice.
| M.Wt | 406.453 | |
| Formula | C23H18N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[[[5-(6-Methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]methyl]amino]benzonitrile |
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1. Park CY, et al. Eur J Cancer. 2011 Nov;47(17):2642-53.
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