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Chemical Structure : K02288
CAS No.: 1431985-92-0
Catalog No.: PC-42940Not For Human Use, Lab Use Only.
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4.
K02288 also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM).
K02288 specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.
K02288 inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.
| M.Wt | 352.3838 | |
| Formula | C20H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 58.6 mg/mL |
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| Chemical Name/SMILES |
Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]- |
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1. Sanvitale CE, et al. PLoS One. 2013 Apr 30;8(4):e62721.
2. Mohedas AH, et al. J Med Chem. 2014 Oct 9;57(19):7900-15.
3. Kerr G, et al. Angiogenesis. 2015 Apr;18(2):209-17.
4. Windhausen T, et al. Molecules. 2015 Apr 24;20(5):7586-601.
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