LY-364947 | TGFβR1 inhibitor | Probechem Biochemicals

Chemical Structure : LY-364947

CAS No.: 396129-53-6

LY-364947 (HTS466284)

Catalog No.: PC-24919Not For Human Use, Lab Use Only.

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II.

Packing	Price	Stock
5 mg	$48	In stock
10 mg	$68	In stock
25 mg	$118	In stock
50 mg	$188	In stock
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Biological Activity

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II.

Physicochemical Properties

M.Wt	272.31
Formula	C17H12N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

References

1. Peng SB, et al. Biochemistry, 2005, 44(7), 2293-2304.

2. Oka M, et al. Blood, 2008, 111(9), 4571-4579.

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LY-364947 (HTS466284)

Biological Activity

Physicochemical Properties

References

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