Chemical Structure : C-5635020
CAS No.:
331749-64-5
C-5635020
(C5635020)
Catalog No.: PC-23803Not For Human Use, Lab Use Only.
C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol.
C-5635020 has preference for TGFβ RII than TGFβ RI.
C-5635020 targets the kinase domain of TGFβ RII with superior binding affinities compared to the standard drug, staurosporine.
C-5635020 inhibited TGFβ RII and TGFβ induced phosphorylation on Smad 2/3 in MDA-MB 231 and MCF-7 cells, inhibited the proliferation of both cell lines with GI50 of 204.2 nM for MDA-MB 231 and 154.9 nM for MCF-7, respectively.
C-5635020 induced apoptosis in breast cancer cells.
Physicochemical Properties
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M.Wt
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371.44
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Formula
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C27H17NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-(2-methyl phenyl)-9H-benzo[f]indeno[2,1-c]quinolin-9-one
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References
1. Al Shahrani M, et al. Biochem Biophys Res Commun. 2025 Jan 2;746:151225.
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