C-5635020 | TGFβ RII inhibitor | Probechem Biochemicals

Chemical Structure : C-5635020

C-5635020 (C5635020)

Catalog No.: PC-23803Not For Human Use, Lab Use Only.

C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol.

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Biological Activity

C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβRI with a docking score of -13.9 kcal/mol.
C-5635020 has preference for TGFβ RII than TGFβ RI.
C-5635020 targets the kinase domain of TGFβ RII with superior binding affinities compared to the standard drug, staurosporine.
C-5635020 inhibited TGFβ RII and TGFβ induced phosphorylation on Smad 2/3 in MDA-MB 231 and MCF-7 cells, inhibited the proliferation of both cell lines with GI50 of 204.2 nM for MDA-MB 231 and 154.9 nM for MCF-7, respectively.
C-5635020 induced apoptosis in breast cancer cells.

Physicochemical Properties

M.Wt	371.44
Formula	C27H17NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(2-methyl phenyl)-9H-benzo[f]indeno[2,1-c]quinolin-9-one

References

1. Al Shahrani M, et al. Biochem Biophys Res Commun. 2025 Jan 2;746:151225.

C-5635020 (C5635020)

Biological Activity

Physicochemical Properties

References

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