M4K2304

Chemical Structure : M4K2304

Catalog No.: PC-22014Not For Human Use, Lab Use Only.

M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.

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Biological Activity

M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.
M4K2304 shows cell IC50 of 11 nM in NanoBRET target engagement assay.
M4K2304 also shows high selectivity over ALK1 and ALK6, ALK4, as well as favorable kinome-wide selectivity.
M4K2304 demonstrates excellent kinome-wide selectivity, inhibiting only 3% of 422 kinases by more than 50% at 1 uM.

Physicochemical Properties

M.Wt	460.58
Formula	C27H32N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-9-(piperazin-1-yl)-4-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[c]pyrido[3,4-e]azepine

References

1. González-Álvarez H, et al. J Med Chem. 2024 Mar 18.

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M4K2304

Biological Activity

Physicochemical Properties

References

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