Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-TGF-beta/Smad-TGF beta Receptor (TGFBR)-KTI-2338
KTI-2338

Chemical Structure : KTI-2338

CAS No.: 2248155-16-8

Add to Favorites

KTI-2338 (KTI2338, KTI 2338)

Catalog No.: PC-25943Not For Human Use, Lab Use Only.

KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1.
    KTI-2338 decreases Activin A-stimulated pSMAD1/5/9 signaling in FOP fibroblasts.
    KTI-2338 (223 nM) significantly reduces ID1 and ID2 expression in FOP fibroblasts.
    KTI-2338 successfully reduces osteogenic gene expression in both fibroblasts and transdifferentiated osteoblast-like cells.

    Physicochemical Properties

    M.Wt 447.52
    Formula C24H26FN7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-fluoro-6-methoxy-4-(6-(3-(4-methylpiperazin-1-yl)azetidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

    References

    1. Rosenberg NM, et al. Pharmaceutics. 2025 Dec 10;17(12):1590.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: