δ-secretase inhibitor 11 is a selective, orally bioactive and brain permeable δ-secretase (AEP, delta-secretase) inhibitor with IC50 of 700 nM.
δ-secretase inhibitor 11 displays 45-fold selectivity over caspases-3, and >100-fold over caspase-8, cathepsin-S and L.
δ-secretase inhibitor 11 has IC50 of 800 nM in Pala cells, reduces tau and APP cleavage, ameliorates synapse loss and augments long-term potentiation, resulting in protection of memory in mouse models of Alzheimer's disease.
Physicochemical Properties
M.Wt
220.232
Formula
C10H12N4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
7-morpholinobenzo[c][1,2,5]oxadiazol-4-amine
References
1. Zhang Z, et al. Nat Commun. 2017 Mar 27;8:14740.
