Chemical Structure : (-)-U-50488 hydrochloride
CAS No.: 114528-79-9
Catalog No.: PC-60715Not For Human Use, Lab Use Only.
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist (Kd=2.2 nM) with no μ-opioid antagonist effects.
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(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist (Kd=2.2 nM) with no μ-opioid antagonist effects.
(-)-U-50488 hydrochloride shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.
| M.Wt | 405.79 | |
| Formula | C19H26Cl2N2O.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride |
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1. Tao PL, et al. Eur J Pharmacol. 1994 May 2;256(3):281-6.
2. Suarez-Roca H, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):648-53.
3. Su MT, et al. Br J Pharmacol. 1998 Feb;123(4):625-30.
4. Vonvoigtlander PF, et al. J Pharmacol Exp Ther. 1983 Jan;224(1):7-12.

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