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(-)-U-50488 hydrochloride

Chemical Structure : (-)-U-50488 hydrochloride

CAS No.: 114528-79-9

(-)-U-50488 hydrochloride (U50488;U-50488)

Catalog No.: PC-60715Not For Human Use, Lab Use Only.

The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects; shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.

Anxiety

Discontinued

Physicochemical Properties

M.Wt 405.79
Formula C19H26Cl2N2O.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

References

1. Tao PL, et al. Eur J Pharmacol. 1994 May 2;256(3):281-6.

2. Suarez-Roca H, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):648-53.

3. Su MT, et al. Br J Pharmacol. 1998 Feb;123(4):625-30.

4. Vonvoigtlander PF, et al. J Pharmacol Exp Ther. 1983 Jan;224(1):7-12.

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