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Chemical Structure : (R)-9b
Catalog No.: PC-70152Not For Human Use, Lab Use Only.
Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
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Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
(R)-9b also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src.
(R)-9b potently suppresses proliferation of human cancer cell lines with IC50 <2 uM.
(R)-9b exhibits considerable stability in human plasma and a long half-life.
| M.Wt | 402.927 | |
| Formula | C20H27ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8.
2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983.
3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63.
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