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You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Ack1 (TNK2)-(R)-9bMS
(R)-9bMS

Chemical Structure : (R)-9bMS

CAS No.: 2255306-73-9

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(R)-9bMS ((R)-9b methanesulfonate)

Catalog No.: PC-70151Not For Human Use, Lab Use Only.

(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
    (R)-9b also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src.
    (R)-9b potently suppresses proliferation of human cancer cell lines with IC50 <2 uM.
    (R)-9b exhibits considerable stability in human plasma and a long half-life.

    Physicochemical Properties

    M.Wt 499.027
    Formula C21H31ClN6O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-chloro-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4-diamine methanesulfonate

    References

    1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8.

    2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983.

    3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63.

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