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(R)-AS-1

Chemical Structure : (R)-AS-1

CAS No.: 2506367-95-7

(R)-AS-1 (EAAT2 PAM)

Catalog No.: PC-49277Not For Human Use, Lab Use Only.

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

    Physicochemical Properties

    M.Wt 260.293
    Formula C14H16N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)- N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide

    References

    1. Michał Abram, et al. J Med Chem. 2022 Aug 19. doi: 10.1021/acs.jmedchem.2c00534.

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