(R)-AS-1 | EAAT2 PAM | Probechem Biochemicals

Chemical Structure : (R)-AS-1

(R)-AS-1 (EAAT2 PAM)

Catalog No.: PC-49277Not For Human Use, Lab Use Only.

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

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Biological Activity

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

Physicochemical Properties

M.Wt	260.293
Formula	C14H16N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)- N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide

References

1. Michał Abram, et al. J Med Chem. 2022 Aug 19. doi: 10.1021/acs.jmedchem.2c00534.

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(R)-AS-1 (EAAT2 PAM)

Biological Activity

Physicochemical Properties

References

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