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Chemical Structure : (R)-AS-1
Catalog No.: PC-49277Not For Human Use, Lab Use Only.
(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.
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(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.
| M.Wt | 260.293 | |
| Formula | C14H16N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michał Abram, et al. J Med Chem. 2022 Aug 19. doi: 10.1021/acs.jmedchem.2c00534.
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